2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin
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منابع مشابه
A Mouse Model of Acute and Delayed Complications of Sulfur Mustard Analogue, 2-Chloroethyl Ethyl Sulfide
Background: Numerous studies have been conducted on humans, animals, and cell cultures exposed to Sulfur Mustard (SM). However, the precise mechanism and cause or long-term pattern of SM injuries are not well defined. There is no protocol available for treating people with severe eye, lung, and skin ailments. The current study aimed to develop an animal model of the acute and delayed complicati...
متن کاملSynthesis of MgO Nanoparticales and Identificationof Their Destructive Reaction Products by 2-Chloroethyl Ethyl Sulfide
Nanocrystalline magnesium oxides were prepared by sol–gel method and were characterized by X-ray diffraction, N2-BET, SEM and infrared spectroscopy techniques. The results confirmed the formation of Nano- MgO materials with crystallite size in range of 5-20 nm and surface areas of 336-556m2/g. The product has been tested as destructive adsorbent for the decontamination of (2-chloroethyl) et...
متن کاملInhibition of two-stage carcinogenesis in mouse skin with bis(2-chloroethyl)sulfide.
ICR/Ha Swiss mice, 30 females/group, were given a single application of 20 mug 7,12-dimethylbenz(a)anthracene, followed 2 weeks later by three times weekly applications of phorbol myristate acetate (PMA), 2.5 mug/application. In the accompanying inhibition experiments, sulfur mustard [SM; bis(2-chloroethyl)sulfide] was applied at a dose of 20 mug/application during the promotion phase, either o...
متن کاملsynthesis of mgo nanoparticales and identificationof their destructive reaction products by 2-chloroethyl ethyl sulfide
nanocrystalline magnesium oxides were prepared by sol–gel method and were characterized by x-ray diffraction, n2-bet, sem and infrared spectroscopy techniques. the results confirmed the formation of nano- mgo materials with crystallite size in range of 5-20 nm and surface areas of 336-556m2/g. the product has been tested as destructive adsorbent for the decontamination of (2-chloroethyl) ethyl ...
متن کاملAirway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide.
Acute lung injury is a principal cause of morbidity and mortality in response to mustard gas (SM) inhalation. Obstructive, fibrin-containing airway casts have recently been reported in a rat inhalation model employing the SM analog 2-chloroethyl ethyl sulfide (CEES). The present study was designed to identify the mechanism(s) causing activation of the coagulation cascade after CEES-induced airw...
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ژورنال
عنوان ژورنال: Toxicology
سال: 2011
ISSN: 0300-483X
DOI: 10.1016/j.tox.2011.01.021